A Complete Solventless Extraction Platform
Four patented technologies. One integrated process. From fresh biomass to high-purity products, without a single chemical solvent.
Herbolea Biotech™ has developed a proprietary platform of four interconnected, patented extraction technologies that cover the entire value chain: from enzymatic extraction to concentration, purification, and fractionation. Our solventless approach sets new global standards in efficiency, purity, and sustainability, enabling industrial partners to produce pharmaceutical-grade natural ingredients at scale.
Four Patented Technologies. One Integrated Platform
Bio-Herbolysis™
Enzyme-Assisted Lipid Extraction - Patent: US10973864B2
Bio-Herbolysis™ is our foundational patented technology — a gentle, highly efficient enzymatic process that extracts and stabilizes the complete phyto-complex of any botanical material into a lipid carrier, without any chemical solvent.
Acidic Form Preservation
The only scalable industrial method capable of preserving cannabinoid acidic forms during purification. Recent medical research shows acidic cannabinoids are over 1,000× more effective at activating serotonin receptors, reducing nausea and anxiety.
True Full-Spectrum
The enzymatic approach preserves the entire plant fingerprint — cannabinoids, terpenes, terpenoids, flavonoids — in their natural ratios, delivering a genuine entourage effect that isolated compounds cannot replicate.
Ultra-Low Energy
Operating at just 0.15 kWh per kg of fresh material, DistillAc™ consumes up to 90% less energy than conventional CO₂ or solvent-based extraction methods, dramatically reducing operational costs and environmental footprint.
GMP-Ready
Fully automated, stainless steel construction with validated procedures including IOPQ protocols and SOPs, enabling seamless integration into pharmaceutical and nutraceutical manufacturing environments.
Food-Grade Inputs
Uses only enzymes and lipids as processing aids — no CO₂, ethanol, butane, or any chemical solvent — ensuring clean-label compliance and eliminating residual solvent concerns in the final product.
Hydrocan™
Solventless Cannabinoid Concentration & THC Removal - Patent: EP4208274B1
Hydrocan™ is our patented alkaline wash purification technology that selectively concentrates cannabinoids while removing THC to pharmaceutical compliance levels — all without chemical solvents.
Selective THC Removal
Achieves THC content below 0.3% — or even below 0.1% by weight — meeting the strictest pharmaceutical and regulatory requirements worldwide without compromising the concentration of other valuable cannabinoids.
Preserves Cannabinoid Ratios
The weight ratio between the two main cannabinoids in the concentrate differs less than 10% from the original lipid extract, maintaining the plant's natural profile and ensuring a consistent therapeutic fingerprint.
High Potency Concentration
Delivers concentrates reaching up to 95% total cannabinoid content by dry weight, rivaling the purity of chromatography-based methods while using a fundamentally simpler and more cost-effective process.
Broad Pharmaceutical Applications
Suitable as active pharmaceutical ingredient (API) across nutraceutical, cosmetic, food, feed, antimicrobial, and biopesticide sectors, with patent claims covering the full spectrum of regulated end uses.
No Chromatography Required
Eliminates the need for expensive chromatographic equipment used in conventional THC remediation, replacing it with a simple alkaline wash that is inherently scalable and dramatically reduces capital and operating costs.
DistillAc™
Molecular Distillation with Acidic Form Preservation - Patent: WO2021037343A1
DistillAc™ is our patented molecular vacuum distillation technology that purifies cannabinoid extracts to pharmaceutical-grade potency while uniquely preserving their acidic forms — a capability no other scalable industrial process can deliver.
Acidic Form Preservation
Maintains CBDA, THCA, and other acidic cannabinoids that conventional distillation processes destroy through decarboxylation, preserving specific bioactive targets for therapeutic applications.
Pharmaceutical-Grade Purity
Achieves concentrates with ≥40% total cannabinoids through molecular vacuum distillation (120–260°C, <0.04 mbar), removing impurities without compromising chemical integrity.
Scalable Industrial Process
The only commercially viable method combining vacuum distillation and lipid-based extraction to deliver both purity and acidic form preservation at manufacturing scale.
Versatile Lipid Carrier Compatibility
Works with paraffin, vegetable oils, coconut oil, ethyl acetate, glycerine, d-limonene, and more, enabling customized formulations for different cannabinoid profiles.
Cannabinoid Ratio Retention
Preserves concentration ratios from the source material (<10% variance between primary cannabinoids), maintaining the entourage effect and the plant's unique cannabinoid signature.
HYPERHOP™
Solventless Hop Bitter Acids Concentration - Patent: EP4186374A1
Hyperhop™ is our patented technology for the selective concentration of bitter acids from hop plants (Humulus lupulus L.) delivering ultra-high alpha acid concentrates with preserved xanthohumol, entirely without chemical solvents.
Superior Alpha Acid Selectivity
Achieves alpha-to-beta acid ratios up to 20:1, far exceeding conventional CO₂ hop extracts. This translates to more predictable, consistent bittering in brewing and dramatically reduces the variability that brewmasters face with traditional extracts.
Xanthohumol Preservation
Retains at least 1.5% xanthohumol by dry weight — a bioactive prenylated flavonoid with documented anti-inflammatory and antioxidant properties, increasingly valued in nutraceutical applications and functional beverages.
Terpene Recovery
The separated oily phase can be distilled to recover hop-characteristic terpenes, creating an additional revenue stream for brewers and essential oil producers while enabling aroma-specific product formulations.
No CO₂ Required
Eliminates the need for supercritical CO₂ extraction equipment, which demands high-pressure vessels, specialized facilities, and significant capital investment — making advanced hop processing accessible to mid-size producers.
Brewing & Beyond
Beyond bittering applications, the concentrate serves pharmaceutical, nutraceutical, and food industries thanks to its high bioactive content, opening diversified market opportunities from a single production line.
What You Can Produce
Herbolea technologies serve a wide spectrum of industries, delivering tailored products that meet the highest standards of purity, potency, and regulatory compliance.
Pharmaceutical & Medical
GMP-grade cannabinoid API (active pharmaceutical ingredients)
THC-free concentrates (<0.1%) for regulated markets
Acidic-form distillates (CBDA, THCA) for advanced medical research
Standardized full-spectrum extracts for clinical formulations
Nutraceutical & Wellness
Full-spectrum CBD oils and tinctures
High-potency cannabinoid concentrates (up to 95%)
Broad-spectrum distillates with preserved terpene profiles
Standardized botanical extracts for dietary supplements
Food & Beverage
Hop bitter acid concentrates for craft and industrial brewing
Natural flavoring ingredients from botanical terpenes
Food-grade cannabinoid ingredients for functional foods
Essential oil fractions for beverage flavoring
Cosmetics & Personal Care
Lipid-based botanical extracts for skincare formulations
Terpene-rich essential oil fractions for fragrances
Cannabinoid-infused cosmetic ingredients
Natural bioactive compounds for anti-aging and wellness products
Ready to Transform Your Extraction Process?
Partner with Herbolea Biotech to access the world’s most advanced solventless extraction platform. From pilot to full-scale production, our team delivers turnkey solutions tailored to your industry and regulatory requirements.