A Complete Solventless Extraction Platform

Four patented technologies. One integrated process. From fresh biomass to high-purity products, without a single chemical solvent.

Herbolea Biotech™ has developed a proprietary platform of four interconnected, patented extraction technologies that cover the entire value chain: from enzymatic extraction to concentration, purification, and fractionation. Our solventless approach sets new global standards in efficiency, purity, and sustainability, enabling industrial partners to produce pharmaceutical-grade natural ingredients at scale.

Four Patented Technologies. One Integrated Platform

Bio-Herbolysis™

Enzyme-Assisted Lipid Extraction - Patent: US10973864B2

Bio-Herbolysis™ is our foundational patented technology — a gentle, highly efficient enzymatic process that extracts and stabilizes the complete phyto-complex of any botanical material into a lipid carrier, without any chemical solvent.

Key Advantages

· Wet Processing. Direct processing of fresh plant material eliminates the need for drying, preserving 2.5 times more terpenes compared to dry biomass extraction.

· True Full-Spectrum. The enzymatic approach preserves the entire plant fingerprint — cannabinoids, terpenes, terpenoids, flavonoids — in their natural ratios.

· Ultra-Low Energy. Operating at just 0.15 kWh per kg of fresh material, up to 90% less than conventional extraction methods.

· GMP-Ready. Fully automated, stainless steel construction, validated procedures (IOPQ protocols and SOPs provided).

· Food-Grade Inputs. Only enzymes and lipids — no CO₂, ethanol, butane, or any chemical solvent.

Hydrocan™

Solventless Cannabinoid Concentration & THC Removal - Patent: EP4208274B1

Hydrocan™ is our patented alkaline wash purification technology that selectively concentrates cannabinoids while removing THC to pharmaceutical compliance levels — all without chemical solvents.

Key Advantages

· Selective THC Removal. Achieves THC content below 0.3% or even below 0.1% by weight, meeting the strictest pharmaceutical and regulatory requirements worldwide.

· Preserves Cannabinoid Ratios. The weight ratio between the two main cannabinoids in the concentrate differs less than 10% from the original lipid extract — maintaining the plant’s natural profile.

· High Potency. Concentrates reach up to 95% total cannabinoid content by dry weight.

· Pharmaceutical Applications. Suitable for pharma API, nutraceutical, cosmetic, food, feed, antimicrobial, and biopesticide applications as defined in the patent claims.

· No Chromatography Required. Unlike conventional THC remediation methods that require expensive chromatographic equipment, Hydrocan™ achieves compliance through a simple, scalable process.

DistillAc™

Molecular Distillation with Acidic Form Preservation - Patent: WO2021037343A1

DistillAc™ is our patented molecular vacuum distillation technology that purifies cannabinoid extracts to pharmaceutical-grade potency while uniquely preserving their acidic forms — a capability no other scalable industrial process can deliver.

Key Advantages

· Acidic Form Preservation. The only highly scalable and efficient industrial method capable of preserving cannabinoid acidic forms. Recent medical research shows acidic forms are more than 1,000 times more effective at activating serotonin receptors that reduce nausea and anxiety.

· Pharmaceutical-Grade Purity. 85%+ potency with 99% efficiency, suitable for API production.

· True Full/Broad Spectrum. The distillate consistently replicates the plant’s original fingerprint, maintaining the entourage effect.

· Versatile Input. Can process both raw lipid extracts from Bio-Herbolysis™ and concentrated products from Hydrocan™.

· Unique Product Positioning. Acidic-form distillates command premium pricing in pharmaceutical and medical markets.

HYPERHOP™

Solventless Hop Bitter Acids Concentration - Patent: EP4186374A1

Hyperhop™ is our patented technology for the selective concentration of bitter acids from hop plants (Humulus lupulus L.) delivering ultra-high alpha acid concentrates with preserved xanthohumol, entirely without chemical solvents.

Key Advantages

· Superior Alpha Acid Selectivity. Achieves alpha-to-beta acid ratios up to 20:1, far exceeding conventional CO₂ hop extracts. This translates to more predictable bittering in brewing.

· Xanthohumol Preservation. Retains at least 1.5% xanthohumol by dry weight — a bioactive prenylated flavonoid with documented anti-inflammatory and antioxidant properties, increasingly valued in nutraceutical applications.

· Terpene Recovery. The separated oily phase can be distilled to recover hop-characteristic terpenes, creating an additional revenue stream for brewers and essential oil producers.

· No CO₂ Required. Eliminates the need for supercritical CO₂ extraction equipment, which requires high-pressure vessels, specialized facilities, and significant capital investment.

· Brewing & Beyond. Beyond brewing, the concentrate has applications in pharmaceutical, nutraceutical, and food industries due to its high bioactive content.

What You Can Produce

Herbolea technologies serve a wide spectrum of industries, delivering tailored products that meet the highest standards of purity, potency, and regulatory compliance.

Pharmaceutical & Medical

·       GMP-grade cannabinoid API (active pharmaceutical ingredients)

·       THC-free concentrates (<0.1%) for regulated markets

·       Acidic-form distillates (CBDA, THCA) for advanced medical research

·       Standardized full-spectrum extracts for clinical formulations

Nutraceutical & Wellness

·       Full-spectrum CBD oils and tinctures

·       High-potency cannabinoid concentrates (up to 95%)

·       Broad-spectrum distillates with preserved terpene profiles

·       Standardized botanical extracts for dietary supplements

Food & Beverage

·       Hop bitter acid concentrates for craft and industrial brewing

·       Natural flavoring ingredients from botanical terpenes

·       Food-grade cannabinoid ingredients for functional foods

·       Essential oil fractions for beverage flavoring

Cosmetics & Personal Care

·       Lipid-based botanical extracts for skincare formulations

·       Terpene-rich essential oil fractions for fragrances

·       Cannabinoid-infused cosmetic ingredients

·       Natural bioactive compounds for anti-aging and wellness products

Ready to Transform Your Extraction Process?

Partner with Herbolea Biotech to access the world’s most advanced solventless extraction platform. From pilot to full-scale production, our team delivers turnkey solutions tailored to your industry and regulatory requirements.